Author: Seemann, Stefan E.; Gorodkin, Jan; Backofen, Rolf
Title: Unifying evolutionary and thermodynamic information for RNA folding of multiple alignments Document date: 2008_10_4
ID: wtvfow2f_8
Snippet: One example is the maximum expected accuracy (MEA) method originally introduced by ref. (30) and successfully applied to sequence alignment in ProbCons (31) and to RNA structure prediction in CONTRAfold (3). A partition function version of the Sankoff algorithm (which is related to MEA scoring) was introduced in ref. (32) . Another example is Pfold itself, since the current implementation does not use the maximum likelihood approach originally in.....
Document: One example is the maximum expected accuracy (MEA) method originally introduced by ref. (30) and successfully applied to sequence alignment in ProbCons (31) and to RNA structure prediction in CONTRAfold (3). A partition function version of the Sankoff algorithm (which is related to MEA scoring) was introduced in ref. (32) . Another example is Pfold itself, since the current implementation does not use the maximum likelihood approach originally introduced in ref. (33) , but is based on reliability scores (27) , which can be interpreted as a variant of MEA scoring.
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