Author: Wang, Shiliang; Sundaram, Jaideep P.; Stockwell, Timothy B.
Title: VIGOR extended to annotate genomes for additional 12 different viruses Document date: 2012_6_4
ID: wd3ir3wg_5
Snippet: In addition to the viruses listed earlier, measles virus, mumps virus, rubella virus, norovirus, metapneumovirus (MPV), respiratory syncytial virus (RSV), human parainfluenza virus 1 (hPIV-1) and 3 (hPIV-3), Venezuelan equine encephalitis virus (VEEV), yellow fever virus (YFV) and Japanese encephalitis virus (JEV) are also being sequenced by GSCID at JCVI. In order to validate and accurately annotate these genomes, viral species-specific protein .....
Document: In addition to the viruses listed earlier, measles virus, mumps virus, rubella virus, norovirus, metapneumovirus (MPV), respiratory syncytial virus (RSV), human parainfluenza virus 1 (hPIV-1) and 3 (hPIV-3), Venezuelan equine encephalitis virus (VEEV), yellow fever virus (YFV) and Japanese encephalitis virus (JEV) are also being sequenced by GSCID at JCVI. In order to validate and accurately annotate these genomes, viral species-specific protein databases have been created and VIGOR's capabilities were enhanced to detect the new species-specific gene features, such as RNA editing and stop codon read-through. The accuracy of gene predictions of this enhanced version has been evaluated against the same viral annotations available at NCBI. VIGOR was also extended to predict genes correctly for related viruses, such as alphavirus and Sendai virus.
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