Author: Siddharta, Anindya; Pfaender, Stephanie; Vielle, Nathalie Jane; Dijkman, Ronald; Friesland, Martina; Becker, Britta; Yang, Jaewon; Engelmann, Michael; Todt, Daniel; Windisch, Marc P.; Brill, Florian H.; Steinmann, Joerg; Steinmann, Jochen; Becker, Stephan; Alves, Marco P.; Pietschmann, Thomas; Eickmann, Markus; Thiel, Volker; Steinmann, Eike
Title: Virucidal Activity of World Health Organization–Recommended Formulations Against Enveloped Viruses, Including Zika, Ebola, and Emerging Coronaviruses Document date: 2017_3_15
ID: qcwvsxgn_9
Snippet: Concentrations at which the formulations reached the half maximal virus inactivation effective concentration (EC 50 ) were determined using nonlinear regression using the robust fitting method on the normalized 50% tissue culture infectious dose (TCID 50 ) data implemented in GraphPad Prism version 6.07 for Windows. The mean TCID 50 of 2 individual experiments and standard deviations of means were also calculated using GraphPad Prism. Significanc.....
Document: Concentrations at which the formulations reached the half maximal virus inactivation effective concentration (EC 50 ) were determined using nonlinear regression using the robust fitting method on the normalized 50% tissue culture infectious dose (TCID 50 ) data implemented in GraphPad Prism version 6.07 for Windows. The mean TCID 50 of 2 individual experiments and standard deviations of means were also calculated using GraphPad Prism. Significance of differences in mean EC 50 obtained for the viruses between WHO formulations I and II was tested using 2-tailed Wilcoxon matched-pairs signed rank test (P < .01).
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