Author: Sneha Rath; Eliza Prangley; Jesse Donovan; Kaitlin Demarest; Yigal Meir; Ned Wingreen; Alexei Korennykh
Title: Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response Document date: 2018_12_4
ID: ng5c7xai_80
Snippet: RNase L does not degrade A, therefore we set β 2 = 0. The solution of these equations is given by ln For more general parameter values, note that if we define γ = β 1 / , we can write λ = · , which is always positive. Based on this relationship, even if the decay exponent β 1 is very large (i.e. 2-5AMD is very strong), as long as a stable activator is . CC-BY 4.0 International license is made available under a The copyright holder for this .....
Document: RNase L does not degrade A, therefore we set β 2 = 0. The solution of these equations is given by ln For more general parameter values, note that if we define γ = β 1 / , we can write λ = · , which is always positive. Based on this relationship, even if the decay exponent β 1 is very large (i.e. 2-5AMD is very strong), as long as a stable activator is . CC-BY 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/484675 doi: bioRxiv preprint present in the positive feedback loop there will be exponential growth of IFNs due to the activator gradually accumulating and leading to faster IFN mRNA synthesis.
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