Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality

Seo, Sachiko; Waghmare, Alpana; Scott, Emily M; Xie, Hu; Kuypers, Jane M; Hackman, Robert C.; Campbell, Angela P.; Choi, Su-Mi; Leisenring, Wendy M.; Jerome, Keith R.; Englund, Janet A.; Boeckh, Michael

Patients' demographic characteristics were summarized and compared between URI and LRI or among LRI with different viruses (HRV, RSV, PIV, and Influenza virus) using chi-square or Fisher's exact test for categorical variables and Wilcoxon rank sum test for continuous variables (as appropriate). The probability of overall survival was estimated using the Kaplan-Meier method. The probability of mortality after HRV URI was estimated by cumulative incidence curves, treating progression to LRI as a competing risk. The probability of mortality from respiratory failure was estimated by cumulative incidence curves, treating death due to other causes as a competing risk. The log-rank test was used to compare hazards of time-to-event outcomes among patients' characteristics. Cox proportional hazards models were used to evalu-Human rhinovirus infections in HCT recipients haematologica | 2017; 102(6)