Selected article for: "cell gene expression and gene expression"
Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments
  • Document date: 2018_6_5
    • ID: ltb6l5xz_1
    Snippet: Schizophrenia is a devastating illness that affects over 2 million people in the U.S. and displays a wide range of symptoms (1) (2) (3) (4) (5) (6) . Cognitive impairment is a hallmark feature of the illness, and antipsychotics have poor efficacy in treating cognitive decline (7, 8) . The dorsolateral prefrontal cortex (DLPFC) is a brain region heavily implicated in the pathophysiology of schizophrenia, possibly contributing to defects in working.....
    Document: Schizophrenia is a devastating illness that affects over 2 million people in the U.S. and displays a wide range of symptoms (1) (2) (3) (4) (5) (6) . Cognitive impairment is a hallmark feature of the illness, and antipsychotics have poor efficacy in treating cognitive decline (7, 8) . The dorsolateral prefrontal cortex (DLPFC) is a brain region heavily implicated in the pathophysiology of schizophrenia, possibly contributing to defects in working memory (9) . A variety of abnormalities have been reported in the DLPFC of schizophrenia patients, including changes in gene expression, cell density, receptor binding, and cerebral blood flow (10) (11) (12) .

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