Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments

Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith

To generate the top pathways for GluN1 knockdown mice we input the top 20 increased proteins in GluN1 knockdown mice relative to WT mice from LCMS experiments into Ingenuity Pathway Analysis (IPA). The top 5 implicated pathways are reported in Figure 5B . The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/338392 doi: bioRxiv preprint experiment and on Days 7 and 14. Food was also weighed throughout experiments ( Figure S18 ). On Day 7, all mice had their locomotor activity and stereotypy behavior measured in the Open Field Test. On day 9, mice were tested on the Elevated Plus Maze (EPM). Days 10 through 12, mice were tested in the puzzle box assay. Day 15 mice were subjected to the social affiliative paradigm, and finally on day 16, pre-pulse inhibition was tested. A timetable is presented in Table S7 .