Selected article for: "knockdown signature and LDHA knockdown signature"
Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments
  • Document date: 2018_6_5
    • ID: ltb6l5xz_19
    Snippet: We used iLINCS (http://ilincs.org) to retrieve knockdown signatures for each seed gene individually. Each seed gene knockdown signature (GPI knockdown signature, HXK1 knockdown signature, PFKM knockdown signature, PFKL knockdown signature, LDHA knockdown signature, PFKFB2 knockdown signature) is comprised of the transcriptional changes of 978 landmark genes (L1000 genes) when that seed gene is knocked down ( Figure S3 ). Only signatures designa.....
    Document: We used iLINCS (http://ilincs.org) to retrieve knockdown signatures for each seed gene individually. Each seed gene knockdown signature (GPI knockdown signature, HXK1 knockdown signature, PFKM knockdown signature, PFKL knockdown signature, LDHA knockdown signature, PFKFB2 knockdown signature) is comprised of the transcriptional changes of 978 landmark genes (L1000 genes) when that seed gene is knocked down ( Figure S3 ). Only signatures designated to be reproducible and self-connected ("gold") by the Broad Institute are available. When multiple shRNAs are available for gene knock-down experiments, consensus gene knock-down signatures, as defined by iLINCS are used. To minimize variability, we compared signatures for seed genes using one consistent cell line (vertebralcancer of the prostate, VCAP).

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