Selected article for: "seed gene and select seed gene"
Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments
  • Document date: 2018_6_5
    • ID: ltb6l5xz_21
    Snippet: For unsupervised clustering analyses, we used iLINCS to cluster the union of the top 50 differentially expressed L1000 genes from each of the 6 seed gene knockdown signatures using Pearson correlation coefficients (Figures 3 and 4) . Due to gene overlap between top 50 differentially expressed L1000 genes in seed gene knockdown signatures, this resulted in the clustering of expression data for 260 L1000 genes. We next used the dendrogram function .....
    Document: For unsupervised clustering analyses, we used iLINCS to cluster the union of the top 50 differentially expressed L1000 genes from each of the 6 seed gene knockdown signatures using Pearson correlation coefficients (Figures 3 and 4) . Due to gene overlap between top 50 differentially expressed L1000 genes in seed gene knockdown signatures, this resulted in the clustering of expression data for 260 L1000 genes. We next used the dendrogram function in iLINCS to select panels of mRNAs with increased expression across clustered seed gene knockdown signatures ("panels of clustered upregulated genes") and with decreased expression across clustered seed gene knockdown signatures ("panels of clustered downregulated genes").

    Search related documents:
    Co phrase search for related documents
    • clustered downregulated gene and dendrogram function: 1
    • clustered downregulated gene and downregulated gene: 1, 2, 3, 4
    • clustered downregulated gene and seed gene: 1
    • clustered downregulated gene and upregulated gene: 1, 2, 3
    • clustered upregulated gene and dendrogram function: 1
    • clustered upregulated gene and downregulated gene: 1, 2, 3
    • clustered upregulated gene and seed gene: 1
    • clustered upregulated gene and upregulated gene: 1, 2, 3, 4
    • correlation coefficient and Pearson correlation coefficient: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
    • correlation coefficient and seed gene: 1
    • correlation coefficient and upregulated gene: 1, 2
    • decrease expression and increase expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38
    • dendrogram function and downregulated gene: 1
    • dendrogram function and upregulated gene: 1