Author: Jo, Seri; Kim, Suwon; Shin, Dong Hae; Kim, Mi-Sun
Title: Inhibition of SARS-CoV 3CL protease by flavonoids Document date: 2019_11_14
ID: vynk8q8c_17
Snippet: A flavonoid library consisting of 10 different scaffolds was also built (Figure 1 ). It contains five isoflavones, one isoflavane, 17 flavones, 11 flavonols, seven flavanols, seven flavanones, four flavanonol, one prenylflavonoid, nine chalcones and two unclassified flavonoids (Supplementary Table 1 ). We applied the library to assay SARS-CoV 3CLpro. Using 64 flavonoids, an inhibitory effect of each compound at 20 lM was tested. Among them, herba.....
Document: A flavonoid library consisting of 10 different scaffolds was also built (Figure 1 ). It contains five isoflavones, one isoflavane, 17 flavones, 11 flavonols, seven flavanols, seven flavanones, four flavanonol, one prenylflavonoid, nine chalcones and two unclassified flavonoids (Supplementary Table 1 ). We applied the library to assay SARS-CoV 3CLpro. Using 64 flavonoids, an inhibitory effect of each compound at 20 lM was tested. Among them, herbacetin (3,4 0 ,5,7,8-pentahydroxyflavone), rhoifolin (apigenin-7-O-rhamnoglucoside) and pectolinarin (5,7-dihydroxy 4 0 ,6-dimethoxyflavone 7-rutinoside) were found to have prominent inhibitory activity ( Figure 2 ). The binding affinity data were plotted as log inhibitor concentration versus percent fluorescence inhibition (Figure 2 ).
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