Author: Dejnirattisai, Wanwisa; Webb, Andrew I.; Chan, Vera; Jumnainsong, Amonrat; Davidson, Andrew; Mongkolsapaya, Juthathip; Screaton, Gavin
Title: Lectin Switching During Dengue Virus Infection Document date: 2011_6_15
ID: qos9vu3r_28
Snippet: To gain insight into the glycosylation profiles of DENV produced in C6/36, Vero, and DC, purified virus was tested against a panel of lectins with differing carbohydrate-binding specificities by western blot ( Figure 4A ). Among the 5 plant lectins tested, GNA is the only one that selectively interacts with high-and pauci-mannose-type N-glycans. SNA and MAA bind to sialic acid terminally linked to galactose by a2,6 linkage and a2,3 linkage, respe.....
Document: To gain insight into the glycosylation profiles of DENV produced in C6/36, Vero, and DC, purified virus was tested against a panel of lectins with differing carbohydrate-binding specificities by western blot ( Figure 4A ). Among the 5 plant lectins tested, GNA is the only one that selectively interacts with high-and pauci-mannose-type N-glycans. SNA and MAA bind to sialic acid terminally linked to galactose by a2,6 linkage and a2,3 linkage, respectively, which may occur on complex-type N-glycans. DSA recognizes repeating N-acetyllactosamine (galactosyl b1,4 N-acetylglucosamine) sequences; these may also occur on complex-type N-glycans. PNA, unlike DSA, binds preferentially to b1,3-linked terminal galactose, such as galactosyl b1,3 N-acetylgalactosamine, a sequence commonly occurring on O-glycosylated proteins and gangliosides.
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