Author: Imai-Matsushima, Aki; Martin-Sancho, Laura; Karlas, Alexander; Imai, Seiichiro; Zoranovic, Tamara; Hocke, Andreas C.; Mollenkopf, Hans-Joachim; Berger, Hilmar; Meyer, Thomas F.
Title: Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies Document date: 2018_6_22
ID: vopbw1tl_5
Snippet: The growth-promoting effect of feeders has been linked to activation of apoptosis and secretion of growth factors [18, 19] . The same mechanism has been suggested to orchestrate regeneration after tissue damage and it is likely to underlie the robust growth of lung epithelial cells in feeder co-culture [18] . Additionally, the overlapping marker profile of human distal airway epithelial cells (DAECs) with that of regenerating murine epithelial ce.....
Document: The growth-promoting effect of feeders has been linked to activation of apoptosis and secretion of growth factors [18, 19] . The same mechanism has been suggested to orchestrate regeneration after tissue damage and it is likely to underlie the robust growth of lung epithelial cells in feeder co-culture [18] . Additionally, the overlapping marker profile of human distal airway epithelial cells (DAECs) with that of regenerating murine epithelial cells challenged with influenza virus supports this hypothesis [17, 20, 21] . As epithelial cell proliferation is usually followed by coordinated differentiation, we hypothesized that it may be possible to induce differentiation towards alveolar epithelial cells by using factors that induce terminal differentiation of lung progenitors derived from pluripotent stem cells [22] .
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