Author: Vere Hodge, R Anthony
Title: Meeting report: 30th International Conference on Antiviral Research, in Atlanta, GA, USA Document date: 2018_6_28
ID: tudwns0r_42
Snippet: The existing inhibitors have been used to develop a competitive amplified luminescent proximity homogeneous assay screen (ALPHAscreen), which was then used for a target-based screening campaign. From an initial screen of $20,000 compounds, eight new scaffolds that inhibit dengue virus by binding to E and blocking fusion were discovered. IC 50 values for inhibition of the ALPHAscreen assay were well correlated with EC 90 values for antiviral activ.....
Document: The existing inhibitors have been used to develop a competitive amplified luminescent proximity homogeneous assay screen (ALPHAscreen), which was then used for a target-based screening campaign. From an initial screen of $20,000 compounds, eight new scaffolds that inhibit dengue virus by binding to E and blocking fusion were discovered. IC 50 values for inhibition of the ALPHAscreen assay were well correlated with EC 90 values for antiviral activity, validating the target-based assay.
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