Mesodynamics in the SARS nucleocapsid measured by NMR field cycling

Clarkson, Michael W.; Lei, Ming; Eisenmesser, Elan Z.; Labeikovsky, Wladimir; Redfield, Alfred; Kern, Dorothee

Although the technique of measuring relaxation in the fringe field limits the accuracy of the relaxation rates, the data from low-field experiments are qualitatively consistent with the findings from high-field and ultra-high-field spectrometry. With further refinement of equipment and technique it should be possible to improve the sensitivity and accuracy of these measurements substantially. The methods of field-cycling (Roberts et al. 2004; Sivanandam et al. 2009 ) will continue to be very useful in other contexts: for example, experiments with 13 C carbonyls where the absence of an attached proton will probably make measurements to zero field feasible, as they are for 31 P.