Author: Glennie, S; Gritzfeld, J F; Pennington, S H; Garner-Jones, M; Coombes, N; Hopkins, M J; Vadesilho, C F; Miyaji, E N; Wang, D; Wright, A D; Collins, A M; Gordon, S B; Ferreira, D M
Title: Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage Document date: 2015_4_29
ID: st475jw7_18
Snippet: Our results corroborate previous reports showing that carriage isolates presented greater binding to FH than systemic isolates, 27 supporting the relevance of the pneumococcus-FH interaction at the upper airway. However, we could not observe a correlation between viral coinfection and increased colonization density. This is in contrast to findings recently published by Wolter et al., 28 who found a relationship between increased pneumococcal colo.....
Document: Our results corroborate previous reports showing that carriage isolates presented greater binding to FH than systemic isolates, 27 supporting the relevance of the pneumococcus-FH interaction at the upper airway. However, we could not observe a correlation between viral coinfection and increased colonization density. This is in contrast to findings recently published by Wolter et al., 28 who found a relationship between increased pneumococcal colonization density and respiratory virus coinfection in South Africans being treated for acute lower respiratory tract infection. This could be the result of differences in recruitment; our study included healthy, asymptomatic adults, whereas the South African study recruited hospitalized individuals of any age, including 41% who were o2 years old and 51% who were HIV positive.
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