Selected article for: "host cell and protein gene"
Author: Chow, Ken Yan Ching; Hon, Chung Chau; Hui, Raymond Kin Hi; Wong, Raymond Tsz Yeung; Yip, Chi Wai; Zeng, Fanya; Leung, Frederick Chi Ching
Title: Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)
  • Document date: 2016_11_28
    • ID: xuj4yymz_22
    Snippet: The N gene sequence showed high homology with the nucleocapsid protein of other coronaviruses. A putative short lysine-rich nuclear localization signal (KTF-PPTEPKKDKKKKTDEAQ) was identified (12 ) . A potential and well-conserved RNA interaction domain was also identified at the middle region of the gene, in which its basic nature may assist its role (12 , 14 ) . The N protein was reported to activate the AP-1 signal transduction pathway, indicat.....
    Document: The N gene sequence showed high homology with the nucleocapsid protein of other coronaviruses. A putative short lysine-rich nuclear localization signal (KTF-PPTEPKKDKKKKTDEAQ) was identified (12 ) . A potential and well-conserved RNA interaction domain was also identified at the middle region of the gene, in which its basic nature may assist its role (12 , 14 ) . The N protein was reported to activate the AP-1 signal transduction pathway, indicating that the protein may play a role in the regulation of the host cell cycle (36 ) . Apart from the possible role in pathogenicity, N gene was also believed to be the most abundant antigen in the host during the course of infection, making it an excellent candidate for diagnostic purposes. The linear epitopes of the protein have been mapped (35 , 37 , 38 ) , and the possibility of using these antigenic peptides or recombinant proteins in the diagnosis was discussed.

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