Selected article for: "disease severity and increase severity"
Author: Wu, Beibei; Wang, Liyin; Jiang, Lili; Dong, Lili; Xu, Fengli; Lu, Yili; Jin, Jiahui; Wang, Zhanyue; Liang, Guang; Shan, Xiaoou
Title: n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils
  • Document date: 2017_10_25
    • ID: w85t4zz6_19
    Snippet: Sepsis remains a threat to human health, primarily due to a lack of effective therapies (3). With current treatment options, the mortality rate of patients with sepsis remains high at ~30%, and mortality rates increase directly with disease severity (24) . A previous worldwide survey of relevant pathogens in intensive care units found that the majority of patients with sepsis had blood cultures positive for Gram-negative bacteria (25) . LPS, a co.....
    Document: Sepsis remains a threat to human health, primarily due to a lack of effective therapies (3). With current treatment options, the mortality rate of patients with sepsis remains high at ~30%, and mortality rates increase directly with disease severity (24) . A previous worldwide survey of relevant pathogens in intensive care units found that the majority of patients with sepsis had blood cultures positive for Gram-negative bacteria (25) . LPS, a component of the outer leaflet of the outer membrane of Gram-negative bacteria, is a key molecule in the induction of sepsis. Therefore, the present study used LPS to simulate sepsis induced by Gram-negative bacteria infection.

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