Author: Wu, Beibei; Wang, Liyin; Jiang, Lili; Dong, Lili; Xu, Fengli; Lu, Yili; Jin, Jiahui; Wang, Zhanyue; Liang, Guang; Shan, Xiaoou
Title: n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils Document date: 2017_10_25
ID: w85t4zz6_21
Snippet: In our previous study, it was demonstrated that n-butanol extract from Folium isatidis significantly inhibited the activation of TLR4 and its signaling pathways (22) . It has been reported that the systemic activation of TLRs and high levels of TNF-α are involved in the reduction of neutrophil recruitment through the downregulation of CXCR2 in neutrophils (28) . Therefore, it was hypothesized that n-butanol extract from F. isatidis prevents the .....
Document: In our previous study, it was demonstrated that n-butanol extract from Folium isatidis significantly inhibited the activation of TLR4 and its signaling pathways (22) . It has been reported that the systemic activation of TLRs and high levels of TNF-α are involved in the reduction of neutrophil recruitment through the downregulation of CXCR2 in neutrophils (28) . Therefore, it was hypothesized that n-butanol extract from F. isatidis prevents the downregulation of CXCR1 and CXCR2 through the activation of TLR4 and secretion of TNF-α.
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