Author: Choi, Kang-Seuk
Title: Newcastle disease virus vectored vaccines as bivalent or antigen delivery vaccines Document date: 2017_7_26
ID: vk59ghjm_24
Snippet: Global epizootic episodes of H5 HPAIV in wild birds and poultry and their potential to cause a pandemic in humans have driven the development of effective H5 HPAIV vaccines [42] , which aim to maintain food security and reduce viral load in the environment. Since the mid-2000s, vaccination programs designed to protect poultry from H5 HPAIV have been implemented by several countries in which the virus is enzootic, including China (and Hong Kong), .....
Document: Global epizootic episodes of H5 HPAIV in wild birds and poultry and their potential to cause a pandemic in humans have driven the development of effective H5 HPAIV vaccines [42] , which aim to maintain food security and reduce viral load in the environment. Since the mid-2000s, vaccination programs designed to protect poultry from H5 HPAIV have been implemented by several countries in which the virus is enzootic, including China (and Hong Kong), Egypt, Indonesia, and Vietnam [43] . In general, conventional highly pathogenic avian influenza (HPAI) vaccines for poultry comprise killed virus prepared from a low pathogenic strain or, more recently, from a reverse genetic engineered low pathogenic reassortant virus that derives its hemagglutinin (HA) and neuraminidase genes from a field-virulent virus and its six internal genes from A/ Puerto Rico/8/34 (PR8) [44] . Killed avian influenza virus (AIV) vaccines have limitations, including high production costs, poor immunogenicity, and problems with mass vaccination.
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