Author: Willemsen, Anouk; Zwart, Mark P
Title: On the stability of sequences inserted into viral genomes Document date: 2019_11_14
ID: vv5gpldi_95
Snippet: When comparing all viral genome architectures, we conclude that that genomic stability is not a fixed, intrinsic property. Although we show that insert stability depends on the nature of the genome, the site and size of the insert and the recombination rate, the host species and demographic conditions (i.e. population and bottleneck size) can radically change viral evolutionary dynamics. We have illustrated this idea with a simple simulation mode.....
Document: When comparing all viral genome architectures, we conclude that that genomic stability is not a fixed, intrinsic property. Although we show that insert stability depends on the nature of the genome, the site and size of the insert and the recombination rate, the host species and demographic conditions (i.e. population and bottleneck size) can radically change viral evolutionary dynamics. We have illustrated this idea with a simple simulation model that considers the effect of genetic bottlenecks (Box 1), where the observed stability of the viral genome decreases as the bottleneck is widened. The interplay between all factors affecting insert stability appears to be complex and unexpectedly sensitive to the exact conditions under which a virus population evolves.
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