Outbreak of febrile respiratory illness associated with human adenovirus type 14p1 in Gansu Province, China

Huang, Guohong; Yu, Deshan; Zhu, Zhen; Zhao, Hai; Wang, Peng; Gray, Gregory C.; Meng, Lei; Xu, Wenbo

Recently, another genome sequence of HAdV-14p1 isolated in Guangzhou City in 2010 from a 17-month-old child with acute suppurative tonsillitis was published. 34 Increasing evidence suggested HAdV-14p1 was found in China as far back as 2010. The high homology between HAdV-14p1 isolated from Beijing, Guangzhou, and Gansu between 2010 and 2011 supported the hypothesis of a stable evolution and transmission of HAdV-14p1 in China. In our study, amplifications of the hypervariable regions of the hexon gene from 11 HAdV-positive specimens were identical to HAdV-14p1 and classified as such. As reported by Kajon et al., 35 further molecular typing and analysis aimed at the complete amplification of hexon, fiber, and E1A gene evidenced that the outbreak HAdV-14p1 isolates were nearly identical to other HAdV-14p1 strains isolated in the United States, Europe, and China between 2006 and 2010.