Author: Sneha Rath; Eliza Prangley; Jesse Donovan; Kaitlin Demarest; Yigal Meir; Ned Wingreen; Alexei Korennykh
Title: Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response Document date: 2018_12_4
ID: ng5c7xai_1
Snippet: The innate immune system is activated without the delay needed for antibody production and provides an immediate defense barrier against infections and out-ofcontrol host cells posing danger. In higher vertebrates, the innate immune system relies on interferon (IFN) signaling coupled with a vertebrae-specific pathway of regulated RNA degradation, 2-5A-mediated decay (2-5AMD) (Chakrabarti et al., 2011; Cooper et al., 2014b; Rath et al., 2015) . 2-.....
Document: The innate immune system is activated without the delay needed for antibody production and provides an immediate defense barrier against infections and out-ofcontrol host cells posing danger. In higher vertebrates, the innate immune system relies on interferon (IFN) signaling coupled with a vertebrae-specific pathway of regulated RNA degradation, 2-5A-mediated decay (2-5AMD) (Chakrabarti et al., 2011; Cooper et al., 2014b; Rath et al., 2015) . 2-5AMD is activated in the presence of double-stranded RNA (dsRNA), a pathogen-associated and damageassociated molecular pattern that signals the presence of viruses (Li et al., 2016) and pathologic derepression of endogenous repeat elements of the host (Chiappinelli et al., 2015; Leonova et al., 2013; Li et al., 2017) .
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