Author: Sneha Rath; Eliza Prangley; Jesse Donovan; Kaitlin Demarest; Yigal Meir; Ned Wingreen; Alexei Korennykh
Title: Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response Document date: 2018_12_4
ID: ng5c7xai_5
Snippet: Shortly after activation of 2-5AMD, dsRNA triggers the transcriptional IFN response, leading to upregulation of innate immune mRNAs (Fig. 1A ) (Alisha Chitrakar et al., 2018; Kawai et al., 2005; Liu et al., 2008) . While global translation remains silenced by actively ongoing 2-5AMD, the mRNAs encoding the interferons IFN-β (type I) and IFN-ï¬ (type III) bypass the global inhibition and are actively translated (Alisha Chitrakar et al., 2018) . .....
Document: Shortly after activation of 2-5AMD, dsRNA triggers the transcriptional IFN response, leading to upregulation of innate immune mRNAs (Fig. 1A ) (Alisha Chitrakar et al., 2018; Kawai et al., 2005; Liu et al., 2008) . While global translation remains silenced by actively ongoing 2-5AMD, the mRNAs encoding the interferons IFN-β (type I) and IFN-ï¬ (type III) bypass the global inhibition and are actively translated (Alisha Chitrakar et al., 2018) . Here we employ cell biology, proteomics, transcriptomics and modeling approaches to determine the translation reprogramming mechanism of 2-5AMD and to explain how innate immune mRNAs can evade the translational arrest.
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