Author: Bird, Grace; Braithwaite, Irene; Harper, James; McKinstry, Steven; Koorevaar, Iris; Fingleton, James; Semprini, Alex; Dilcher, Meik; Jennings, Lance; Weatherall, Mark; Beasley, Richard
Title: Protocol for a randomised, single-blind, two-arm, parallel-group controlled trial of the efficacy of rhinothermy delivered by nasal high flow therapy in the treatment of the common cold Document date: 2019_6_19
ID: x2xc1s14_197
Snippet: Statistical analyses will use the intention to treat principle and all participants who are randomised will be included in the analysis. The primary comparison is between rNHF treatment and 'sham' rhinothermy treatment. The primary outcome variable will be analysed by ANCOVA with Day 1 (baseline) MJS as the covariate. An interaction analysis will be used to assess evidence that there are different treatment outcomes for those participants who tes.....
Document: Statistical analyses will use the intention to treat principle and all participants who are randomised will be included in the analysis. The primary comparison is between rNHF treatment and 'sham' rhinothermy treatment. The primary outcome variable will be analysed by ANCOVA with Day 1 (baseline) MJS as the covariate. An interaction analysis will be used to assess evidence that there are different treatment outcomes for those participants who test positive for HRV. A sensitivity analysis will be used to assess evidence there is an interaction between adherence and the primary outcome.
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