Author: Nordén, Rickard; Magnusson, Jesper; Lundin, Anna; Tang, Ka-Wei; Nilsson, Staffan; Lindh, Magnus; Andersson, Lars-Magnus; Riise, Gerdt C; Westin, Johan
Title: Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation Document date: 2018_3_6
ID: zhlvvuj4_44
Snippet: In the present study, mean EBV-DNA levels did not increase as markedly as TTV-DNA levels after transplantation, even though EBV-specific T cells most likely are subverted by immunosuppressive therapy [43] . The seroprevalence pre-LTx and number of patients positive for EBV-DNA at any time during FU were comparable to previous studies [24, 42, 44] . One possible caveat when determining EBV DNA load is the use of valgangciclovir for preventing reac.....
Document: In the present study, mean EBV-DNA levels did not increase as markedly as TTV-DNA levels after transplantation, even though EBV-specific T cells most likely are subverted by immunosuppressive therapy [43] . The seroprevalence pre-LTx and number of patients positive for EBV-DNA at any time during FU were comparable to previous studies [24, 42, 44] . One possible caveat when determining EBV DNA load is the use of valgangciclovir for preventing reactivation or primary infection of CMV. All patients received 3 months of valgangciclovir treatment initially after LTx; there are a few studies showing that valgangciclovir treatment reduces EBV load, which may have affected the results in this study [45, 46] .
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