Author: Wojciechowska, Marzena; Olejniczak, Marta; Galka-Marciniak, Paulina; Jazurek, Magdalena; Krzyzosiak, Wlodzimierz J.
Title: RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders Document date: 2014_10_29
ID: utigp2vi_13
Snippet: When tested in transfected cells, RAN translation has been observed either from expanded (55 and 88-160) or normal (30-50) CGG repeat lengths, with a higher abundance of proteins being expressed from short (∼30 CGG) rather than from longer (∼88 CGG) repeats as determined by western blot (Supplementary Table S1 ). These results may be a consequence of the decreased efficiency of RAN translation from expanded repeats but may also be caused by t.....
Document: When tested in transfected cells, RAN translation has been observed either from expanded (55 and 88-160) or normal (30-50) CGG repeat lengths, with a higher abundance of proteins being expressed from short (∼30 CGG) rather than from longer (∼88 CGG) repeats as determined by western blot (Supplementary Table S1 ). These results may be a consequence of the decreased efficiency of RAN translation from expanded repeats but may also be caused by the limitations of the methods that were used to detect its products, as concluded by Todd et al. (16) .
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