Author: Wojciechowska, Marzena; Olejniczak, Marta; Galka-Marciniak, Paulina; Jazurek, Magdalena; Krzyzosiak, Wlodzimierz J.
Title: RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders Document date: 2014_10_29
ID: utigp2vi_23
Snippet: It is also known from HD studies that toxicity of polyQexpanded Htt depends on its subcellular localization, and the cell nucleus is the primary site of pathogenesis (40, 41) . The RAN-translated proteins accumulate in the cell nucleus and the question may be asked whether they may trigger similar mechanisms of pathogenesis by recruiting essential nuclear proteins and compromising their functions?.....
Document: It is also known from HD studies that toxicity of polyQexpanded Htt depends on its subcellular localization, and the cell nucleus is the primary site of pathogenesis (40, 41) . The RAN-translated proteins accumulate in the cell nucleus and the question may be asked whether they may trigger similar mechanisms of pathogenesis by recruiting essential nuclear proteins and compromising their functions?
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