Author: Wojciechowska, Marzena; Olejniczak, Marta; Galka-Marciniak, Paulina; Jazurek, Magdalena; Krzyzosiak, Wlodzimierz J.
Title: RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders Document date: 2014_10_29
ID: utigp2vi_52
Snippet: In contrast to RAN translation, there are more premises that polyAla-containing proteins produced during frameshifting are cytotoxic. In both SCA3 and HD, frameshifted proteins are present in cells harboring polyQ aggregates and contribute to cell toxicity by changing cell morphology and inducing cell death. They accumulate in intranuclear inclusions and can also be found as perinuclear and cytoplasmic aggregates that colocalize with ubiquitin, a.....
Document: In contrast to RAN translation, there are more premises that polyAla-containing proteins produced during frameshifting are cytotoxic. In both SCA3 and HD, frameshifted proteins are present in cells harboring polyQ aggregates and contribute to cell toxicity by changing cell morphology and inducing cell death. They accumulate in intranuclear inclusions and can also be found as perinuclear and cytoplasmic aggregates that colocalize with ubiquitin, a well-known component of protein inclusions in polyGln disorders (73) .
Search related documents:
Co phrase search for related documents- cell death and ran translation: 1, 2
- cell toxicity and ran translation: 1
- polyGln disorder and ran translation: 1
Co phrase search for related documents, hyperlinks ordered by date