Author: Jefferies, Sarah; Braithwaite, Irene; Walker, Steven; Weatherall, Mark; Jennings, Lance; Luck, Michelle; Barrett, Kevin; Siebers, Robert; Blackmore, Timothy; Beasley, Richard; Perrin, Kyle
Title: Randomized controlled trial of the effect of regular paracetamol on influenza infection Document date: 2015_12_6
ID: vj3m50sb_33
Snippet: To our knowledge this is the first randomized, doubleblind, placebo-controlled trial on the effect of paracetamol in patients with confirmed influenza infection. Regular daily administration of the maximum recommended dose of paracetamol for 5 days had no effect on viral shedding, temperature or clinical symptoms in participants with PCR-proven influenza infection. It is difficult to infer benefit or harm given the lack of effect of regular parac.....
Document: To our knowledge this is the first randomized, doubleblind, placebo-controlled trial on the effect of paracetamol in patients with confirmed influenza infection. Regular daily administration of the maximum recommended dose of paracetamol for 5 days had no effect on viral shedding, temperature or clinical symptoms in participants with PCR-proven influenza infection. It is difficult to infer benefit or harm given the lack of effect of regular paracetamol administered early in the course of an influenza-like illness in this trial; thus, recommendations for or against this practice in the community cannot be made based on these findings.
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