Selected article for: "CRTC1 stabilization and HBx protein expression"
Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription
  • Document date: 2014_11_10
    • ID: qtoygz6w_39
    Snippet: To further investigate mutual stabilization of HBx and CRTC1, we expressed in HepG2 cells CRTC1 and its mutant CRTC1-S167A, either individually or together with HBx. Steady-state levels of both CRTC1 and its S167A mutant were increased when HBx was expressed ( Figure 7A , lanes 5 and 6 compared to 2 and 3). On the other hand, HBx protein expression was more pronounced and a slowmigrating HBx species appeared when CRTC1 or CRTC1-S167A was expresse.....
    Document: To further investigate mutual stabilization of HBx and CRTC1, we expressed in HepG2 cells CRTC1 and its mutant CRTC1-S167A, either individually or together with HBx. Steady-state levels of both CRTC1 and its S167A mutant were increased when HBx was expressed ( Figure 7A , lanes 5 and 6 compared to 2 and 3). On the other hand, HBx protein expression was more pronounced and a slowmigrating HBx species appeared when CRTC1 or CRTC1-S167A was expressed ( Figure 7A , lanes 5 and 6 compared to 4). Hence, CRTC1 and HBx are mutually required for optimal stability and activity.

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