Selected article for: "AUC curve and body weight"
Title: Research Communications of the 24th ECVIM-CA Congress
  • Document date: 2015_1_10
    • ID: r59usk02_67
    Snippet: The levels of all target genes expressed in LV and PWBC were highly correlated each other in linear regression analysis (p < 0.0001; SERCA2a, r = 0.7425, R 2 = 0.5513; PLN, r = 0.7720, R 2 = 0.5959; HAX-1, r = 0.6598, R 2 = 0.4353), although LV and PWBC showed different expression levels in a paired comparison (p < 0.0001). According to the severity of the heart failure (ISACHC), the expression levels of all genes were gradually and significantly.....
    Document: The levels of all target genes expressed in LV and PWBC were highly correlated each other in linear regression analysis (p < 0.0001; SERCA2a, r = 0.7425, R 2 = 0.5513; PLN, r = 0.7720, R 2 = 0.5959; HAX-1, r = 0.6598, R 2 = 0.4353), although LV and PWBC showed different expression levels in a paired comparison (p < 0.0001). According to the severity of the heart failure (ISACHC), the expression levels of all genes were gradually and significantly reduced in both LV and PWBC (p < 0.01). Especially, the SERCA2a and PLN expressed in PWBC could clearly discriminate all ISACHC groups from the control (p < 0.0001). Multivariate regression adjusted by age and body weight revealed that SERCA2a and PLN in LV were negatively associated with LV internal systolic dimension (p = 0.0251, adjusted R 2 = 0.524 and p = 0.012, adjusted R 2 = 0.530, respectively). PLN was also negatively related with LV internal diastolic dimension (p = 0.037, adjusted R 2 = 0.573). Additionally, receiver-operating characteristic analysis using PWBC showed high area under the curve (AUC) values for all target genes on overall ISACHC groups (p < 0.0001; SERCA2a, AUC=0.9212; PLN, AUC=0.8936; HAX-1, AUC=0.8797).

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