Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017

None of the dogs in either group developed diarrhea, though significant changes were seen in the abundance of various bacterial taxa. Significantly decreased Faecalibacterium, Clostridium hiranonis, Turicibacter and Fusobacterium were observed in the fecal microbiota of dogs treated with tylosin at day 7. At 2 months post-tylosin cessation, 5 and 4 of 6 dogs failed to have regained their pre-treatment Faecalibacterium and C. hiranonis levels, respectively. Tylosin administration was not associated with a significant decrease of C. perfringens (P = 0.38), but dogs in the placebo group had a significant decrease in C. perfringens (P = 0.02). There was no significant change in relative abundance of E. coli in dogs treated with tylosin (P = 0.64) or placebo (P = 0.38).