Title: RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS Document date: 2018_12_19
ID: r79h9yzz_1051
Snippet: Canine idiopathic pulmonary fibrosis (CIPF), affecting mainly West Highland White Terriers (WHWTs,) is a chronic progressive interstitial lung disease sharing many similarities with human idiopathic pulmonary fibrosis (IPF). CIPF is characterized by exaggerated accumulation of extracellular matrix (ECM) in the lung parenchyma. Matrixâ€metalloproteinases (MMPs) are proteolytic enzymes capable of degrading ECM. In human IPF, MMPâ€7 has been found.....
Document: Canine idiopathic pulmonary fibrosis (CIPF), affecting mainly West Highland White Terriers (WHWTs,) is a chronic progressive interstitial lung disease sharing many similarities with human idiopathic pulmonary fibrosis (IPF). CIPF is characterized by exaggerated accumulation of extracellular matrix (ECM) in the lung parenchyma. Matrixâ€metalloproteinases (MMPs) are proteolytic enzymes capable of degrading ECM. In human IPF, MMPâ€7 has been found to be a potential diagnostic and prognostic biomarker. The aim of this study was to compare MMPâ€7 activities in serum of CIPF WHWTs, healthy WHWTs and other breed healthy dogs.
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