Title: RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS Document date: 2018_12_19
ID: r79h9yzz_546
Snippet: The high levels of TGFβ were associated with skin ulceration (p = 0.018), tumor necrosis (p = 0.024), high mitotic index (p < 0.001), marked nuclear pleomorphism (p = 0.001), poor tumor differentiation (p < 0.001), high histological grade of malignancy HGM (p < 0.001), presence of neoplastic intravascular emboli (p < 0.001) and presence of lymph node metastases (p < 0.001). The levels of TGFβ were positively correlated with intratumoral FoxP3 (.....
Document: The high levels of TGFβ were associated with skin ulceration (p = 0.018), tumor necrosis (p = 0.024), high mitotic index (p < 0.001), marked nuclear pleomorphism (p = 0.001), poor tumor differentiation (p < 0.001), high histological grade of malignancy HGM (p < 0.001), presence of neoplastic intravascular emboli (p < 0.001) and presence of lymph node metastases (p < 0.001). The levels of TGFβ were positively correlated with intratumoral FoxP3 (r = 0.719; p < 0.001), VEGF (r = 0.378; p = 0.002) and CD31 (r = 0.511; p < 0.001). Tumors with concurrent high expression of TGFβ/FoxP3, TGFβ/VEGF and TGFβ/CD31 markers were associated with parameters of tumor malignancy (high HGM, presence of neoplastic vascular emboli and presence of lymph node metastasis). Additionally tumors with abundant TGFβ and with concurrent high expression of TGFβ/FoxP3, TGFβ/VEGF and TGFβ/CD31 were associated with shorter overall survival (OS) time (p < 0.001). Interestingly TGFβ/FoxP3 class retained the association with shorter OS in multivariate analysis, arising as independent predictor of poor prognosis (9.731 hazard ratio, p < 0.001).
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