Respiratory syncytial virus-associated seizures in Korean children, 2011–2016

Cha, Teahyen; Choi, Young Jin; Oh, Jae-Won; Kim, Chang-Ryul; Park, Dong Woo; Seol, In Joon; Moon, Jin-Hwa

The incidence of RSV-associated neurologic complications varies across studies and study populations. Sweetman et al. 7) reported the incidence of RSV-asso ciated neurologic complications to be 1.2%, which did not include cases with simple febrile seizure, and Ng et al. 12) reported the in cidence of RSV-associated encephalopathy to be 1.8%. In a pediatric intensive care unit (PICU)-based study, Kho et al. 13) reviewed the cases of children between birth and 2 years of age with acute neuro logical symptoms and identified 39.1% of them as RSV-positive. In contrast, Millichap and Wainwright 5) reported that only 1% of the RSV-positive patients were admitted to the PICU with neurolo gic complications. In a study comparing the common viruses res ponsible for febrile seizure, Chung and Wong 14) revealed that the incidence of febrile seizure for RSV was 5.3%, and among them, complex febrile seizure was observed in 13.6% of cases, which was lower than the percentage of such cases for influenza and adenovirus.