Author: Byszewska, Magdalena; Smietanski, Miroslaw; Purta, Elzbieta; Bujnicki, Janusz M
Title: RNA methyltransferases involved in 5' cap biosynthesis Document date: 2015_1_27
ID: sz2531mv_25
Snippet: A complete understanding of RNA cap biosynthesis requires not only structure determination of the enzymes that are well characterized biochemically, but also the identification of the genes and proteins that encode the cap methylation machinery. Some of the prominent enzymatic activities known to exist that are still awaiting unequivocal identification of the corresponding proteins include m 6 A methylation of the first transcribed nucleoside of .....
Document: A complete understanding of RNA cap biosynthesis requires not only structure determination of the enzymes that are well characterized biochemically, but also the identification of the genes and proteins that encode the cap methylation machinery. Some of the prominent enzymatic activities known to exist that are still awaiting unequivocal identification of the corresponding proteins include m 6 A methylation of the first transcribed nucleoside of capped RNAs in humans, and m 6,6 A and m 3 U methylation of the first and the fourth residues in the cap4 structure in capped RNAs in trypanosomes. A comprehensive biochemical and structural characterization of these enzymes could further contribute to the possibility of developing new drugs against trypanosomal parasites and new tools to study RNA metabolism in human cells.
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