Selected article for: "animal model and immune status"
Author: Kerr, William G; Park, Mi-Young; Maubert, Monique; Engelman, Robert W
Title: SHIP deficiency causes Crohn's disease-like ileitis
  • Document date: 2010_10_12
    • ID: qde4so1x_9_1
    Snippet: f both CD4 and CD8 T cells in the small intestine with a concomitant increase in neutrophils at this site. Consistent with altered immune status we find spontaneous development of ileitis with features that closely recapitulate those of CD pathology. In addition, the susceptibility factor for this CD-like ileitis of SHIP-deficient mice appears to be in the haematopoietic compartment, and likely granulocytee monocyte, as the CD-like ileitis was tr.....
    Document: f both CD4 and CD8 T cells in the small intestine with a concomitant increase in neutrophils at this site. Consistent with altered immune status we find spontaneous development of ileitis with features that closely recapitulate those of CD pathology. In addition, the susceptibility factor for this CD-like ileitis of SHIP-deficient mice appears to be in the haematopoietic compartment, and likely granulocytee monocyte, as the CD-like ileitis was transferable to an immunocompetent host following irradiation and reconstitution with SHIP splenocytes, but not following transfer of either T cells or natural killer (NK) cells. Consequently, the SHIP-deficient mouse is the first CD animal model capable of adoptively transferring CD-like disease to an immunocompetent host.

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