Author: Blank, Maximilian F.; Chen, Sifan; Poetz, Fabian; Schnölzer, Martina; Voit, Renate; Grummt, Ingrid
Title: SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription Document date: 2017_3_17
ID: qm9urt2w_55
Snippet: Here we show that deacetylation by SIRT7 augments the kinase activity of CDK9 which is required for CTD phosphorylation and efficient Pol II transcription. Acetylation of CDK9 has no effect on the interaction of P-TEFb with HEXIM1 or 7SK snRNA (31, 32) , indicating that this modification regulates P-TEFb activity independently from the inhibitor function of HEXIM1. However, we found that SIRT7-mediated deacetylation also promotes dissociation of .....
Document: Here we show that deacetylation by SIRT7 augments the kinase activity of CDK9 which is required for CTD phosphorylation and efficient Pol II transcription. Acetylation of CDK9 has no effect on the interaction of P-TEFb with HEXIM1 or 7SK snRNA (31, 32) , indicating that this modification regulates P-TEFb activity independently from the inhibitor function of HEXIM1. However, we found that SIRT7-mediated deacetylation also promotes dissociation of CDK9/cyclin T1 from the inactive P-TEFb/7SK snRNP complex, suggesting that SIRT7 may target another component of the complex to release CDK9/cyclin T1.
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