Author: Liu, Yuan-yuan; Chen, Liang-jun; Zhong, Yan; Shen, Meng-xin; Ma, Nian; Liu, Bing-yu; Luo, Fan; Hou, Wei; Yang, Zhan-qiu; Xiong, Hai-rong
Title: Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo Document date: 2016_3_14
ID: pwlybr2h_38
Snippet: Four animals from each group were sacrificed at 8 dpi, and the brains, lungs and kidneys were collected for pathological examination. As illustrated in Figure 5 , in the viral control group, the lung sections displayed thickened alveolar walls, interstitial lymphocyte and macrophage infiltrations, and hemorrhages. The brain tissues exhibited scattered hemorrhages, congestion, edema, and focal necrosis. The kidney exhibited focal renal interstitia.....
Document: Four animals from each group were sacrificed at 8 dpi, and the brains, lungs and kidneys were collected for pathological examination. As illustrated in Figure 5 , in the viral control group, the lung sections displayed thickened alveolar walls, interstitial lymphocyte and macrophage infiltrations, and hemorrhages. The brain tissues exhibited scattered hemorrhages, congestion, edema, and focal necrosis. The kidney exhibited focal renal interstitial hemorrhages and congestion. Both the pSilencer-S and pSilencer-M treatments decreased the severities of the viral lesions in the brain, lung and kidney tissues.
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