Selected article for: "disease long term and long term"
Author: Zheng, Li-Zhen; Wang, Jia-Li; Kong, Ling; Huang, Le; Tian, Li; Pang, Qian-Qian; Wang, Xin-Luan; Qin, Ling
Title: Steroid-associated osteonecrosis animal model in rats
  • Document date: 2018_2_6
    • ID: tad9jmfp_1
    Snippet: Steroid-associated osteonecrosis (SAON) is a multifactorial bone metabolic disease occurred after long term or/and large dose of corticosteroid therapy attributed to its antiinflammatory and immunomodulatory effects [1] . The pathophysiology underlying the development of SAON includes fat embolism, vascular thrombosis, osteocyte and osteoblast apoptosis and oxidative stress [2] . However, the underlining pathogenesis of SAON is desirable to be st.....
    Document: Steroid-associated osteonecrosis (SAON) is a multifactorial bone metabolic disease occurred after long term or/and large dose of corticosteroid therapy attributed to its antiinflammatory and immunomodulatory effects [1] . The pathophysiology underlying the development of SAON includes fat embolism, vascular thrombosis, osteocyte and osteoblast apoptosis and oxidative stress [2] . However, the underlining pathogenesis of SAON is desirable to be studied by using suitable animal model(s).

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