Author: Zheng, Li-Zhen; Wang, Jia-Li; Kong, Ling; Huang, Le; Tian, Li; Pang, Qian-Qian; Wang, Xin-Luan; Qin, Ling
Title: Steroid-associated osteonecrosis animal model in rats Document date: 2018_2_6
ID: tad9jmfp_43
Snippet: The liver is a vital organ in metabolism, and disorders in the liver reflect the whole body pathophysiological metabolic disorders [42] . In this SAON rat model, the occurrence of hepatic oedema and cell division 2 weeks after SAON induction suggested the acute LPS-induced inflammation injury and liver cells repair progress, which were accompanied by development of osteonecrosis and its repair process at week 2. The fatty liver 6 weeks after SAON.....
Document: The liver is a vital organ in metabolism, and disorders in the liver reflect the whole body pathophysiological metabolic disorders [42] . In this SAON rat model, the occurrence of hepatic oedema and cell division 2 weeks after SAON induction suggested the acute LPS-induced inflammation injury and liver cells repair progress, which were accompanied by development of osteonecrosis and its repair process at week 2. The fatty liver 6 weeks after SAON induction suggested abnormal high lipid levels in corticosteroid-affected metabolic disorders, which corresponded with the fat body including high fat levels in the body composition and high fat level in the bone marrow 6 weeks after SAON induction.
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