Author: Xie, Xin-Hui; Wang, Xin-Luan; Yang, Hui-Lin; Zhao, De-Wei; Qin, Ling
Title: Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview) Document date: 2015_1_13
ID: y6y235hw_62
Snippet: Nonsurgical treatments of ON are limited and are commonly indicated for patients at the early stage of ON with localised necrotic lesions. The objects of such intervention usually focus on pain relief, prevention of ON progression, and improvement of the joint function. According to the different pathophysiologies of SAON, numerous medical and biophysical treatments have been tested and have demonstrated treatment efficacy, especially for patient.....
Document: Nonsurgical treatments of ON are limited and are commonly indicated for patients at the early stage of ON with localised necrotic lesions. The objects of such intervention usually focus on pain relief, prevention of ON progression, and improvement of the joint function. According to the different pathophysiologies of SAON, numerous medical and biophysical treatments have been tested and have demonstrated treatment efficacy, especially for patients in early ON stages, including biological and pharmacological treatments such as statins [45, 55] , bisphosphonates [61] , low molecular weight heparin [62] , stanozolol, iloprost, hyperbaric oxygen, herbal (puerarin and Epimedium) [11, 16] or nonpharmacological treatments including extracorporeal shock wave therapy [63, 64] and electromagnetic therapy [65, 66] .
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