Author: Wenbin Ji; Yibo Luo; Ejaz Ahmad; Song-Tao Liu
Title: Coordination between discrete Mitotic Arrest Deficient 1 (MAD1) domains is required for efficient mitotic checkpoint signaling Document date: 2017_11_1
ID: i4yquw4k_34
Snippet: MPS1 is a key upstream kinase orchestrating the organization of other mitotic checkpoint proteins at unattached kinetochores. It phosphorylates KNL1 to recruit BUB1:BUB3 and BUBR1:BUB3 complexes (reviewed in (1,52) ). It also phosphorylates BUB1 to recruit MAD1:MAD2 (30, 31, 53) . Furthermore, MPS1 phosphorylating MAD1 at T716 may enhance MAD1 binding to CDC20 (30) . Thus MPS1 activity may promote the formation of the MCC by placing all its compo.....
Document: MPS1 is a key upstream kinase orchestrating the organization of other mitotic checkpoint proteins at unattached kinetochores. It phosphorylates KNL1 to recruit BUB1:BUB3 and BUBR1:BUB3 complexes (reviewed in (1,52) ). It also phosphorylates BUB1 to recruit MAD1:MAD2 (30, 31, 53) . Furthermore, MPS1 phosphorylating MAD1 at T716 may enhance MAD1 binding to CDC20 (30) . Thus MPS1 activity may promote the formation of the MCC by placing all its components BUBR1:BUB3, CDC20 and MAD2 in spatial proximity (29, 30) . CDC20 binding to BUB1 or BUBR1 might also help the MCC assembly at unattached kinetochores (54) (55) (56) .
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