Author: Oh, Soo-Jin; Choi, Young-Ki; Shin, Ok Sarah
Title: Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases Document date: 2018_3_1
ID: ta5y54lu_29
Snippet: Thus far, we have reviewed recent advances in the fields of systems immunology and vaccinology, and presented how systems biology-based platforms can be applied to accelerate a deeper understanding of molecular mechanisms of immunity against EIDs. Despite recent advances, there remain computational and biological challenges regarding systems biology approaches. Because the immune response to a vaccine can be affected by a wide range of confoundin.....
Document: Thus far, we have reviewed recent advances in the fields of systems immunology and vaccinology, and presented how systems biology-based platforms can be applied to accelerate a deeper understanding of molecular mechanisms of immunity against EIDs. Despite recent advances, there remain computational and biological challenges regarding systems biology approaches. Because the immune response to a vaccine can be affected by a wide range of confounding factors, including cellular, population, molecular, individual, and technical factors, scientists face many challenges and potential limitations on the analysis of systems-level informatics. These challenges and limitations are described in Fig. 2 .
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