Author: Nicholls, John M
Title: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract Document date: 2013_3_29
ID: vyci1ho3_25
Snippet: The two main cells present in the alveoli are the Type 1 and Type 2 pneumocytes. Type 1 pneumocytes are large and flattened and incapable of replication. The type 2 pneumocytes are smaller and responsible for surfactant production involved in the antiviral defence mentioned above (reviewed in Crouch and Hillaire [48, 49] . When type 1 cells are damaged the type 2 will differentiate into type 1 cells. The diffuse alveolar damage picture seen in th.....
Document: The two main cells present in the alveoli are the Type 1 and Type 2 pneumocytes. Type 1 pneumocytes are large and flattened and incapable of replication. The type 2 pneumocytes are smaller and responsible for surfactant production involved in the antiviral defence mentioned above (reviewed in Crouch and Hillaire [48, 49] . When type 1 cells are damaged the type 2 will differentiate into type 1 cells. The diffuse alveolar damage picture seen in the fatal cases of 1918 H1N1 and H5N1 is due to the destruction of the type 1 pneumocytes with a consequent disruption of the integrity of the vascular-epithelial interface leading to an outpouring of serum proteins including albumin -leading to the hyaline membranes.
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