Author: Nicholls, John M
Title: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract Document date: 2013_3_29
ID: vyci1ho3_45
Snippet: The preceding discussion indicates that the human respiratory tract has developed a complex network of mechanism to ensure that it is protected from the effects of viral infection. The fact that severe influenza can occur in the lower respiratory tract shows that the virus has evolved mechanisms to circumvent this protective mechanism. These can broadly be divided into the surface proteins (HA and HA) that are involved in the extracellular phase .....
Document: The preceding discussion indicates that the human respiratory tract has developed a complex network of mechanism to ensure that it is protected from the effects of viral infection. The fact that severe influenza can occur in the lower respiratory tract shows that the virus has evolved mechanisms to circumvent this protective mechanism. These can broadly be divided into the surface proteins (HA and HA) that are involved in the extracellular phase of exposure (from the environment to the surface of the cell) and then once the virus is in the intracellular environment, the internal genes take over to enhance replication of progeny virions. With regard to the extacellular compartment the role of NA in cleaving the sialylated mucin and glycosylation of the HA has already been discussed.
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