Author: Nicholls, John M
Title: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract Document date: 2013_3_29
ID: vyci1ho3_9
Snippet: The second key factor that allows viral infection is the presence of the NA enzyme that is able to cleave the Sia from an adjacent sugar (often galactose or Gal). This viral NA, however does not cleave all Sia equally and most strains have a preference for cleaving the Sia when it is linked to the Gal in an α2-3 configuration (so called Sia α2-3Gal)(reviewed by Air [20] ). Once inside the cell the internal genes and proteins come into play and .....
Document: The second key factor that allows viral infection is the presence of the NA enzyme that is able to cleave the Sia from an adjacent sugar (often galactose or Gal). This viral NA, however does not cleave all Sia equally and most strains have a preference for cleaving the Sia when it is linked to the Gal in an α2-3 configuration (so called Sia α2-3Gal)(reviewed by Air [20] ). Once inside the cell the internal genes and proteins come into play and play a more dominant role than HA and NA.
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