Author: Hu, Yongwu; Wen, Jie; Tang, Lin; Zhang, Haijun; Zhang, Xiaowei; Li, Yan; Wang, Jing; Han, Yujun; Li, Guoqing; Shi, Jianping; Tian, Xiangjun; Jiang, Feng; Zhao, Xiaoqian; Wang, Jun; Liu, Siqi; Zeng, Changqing; Wang, Jian; Yang, Huanming
Title: The M Protein of SARS-CoV: Basic Structural and Immunological Properties Document date: 2016_11_28
ID: xzlcyn3l_5
Snippet: The ORF of the M protein, which has a defined 5′ transcription regulation sequence (TRS) (5′-CUAAAC-3′), is located between the ORFs for the E protein and PUP3 (putative uncharacterized protein 3) (6). The ORF is 666 nucleotides (nt) long, encoding a protein of 220 (+1) amino acid (a.a.) residues with a predicted molecular weight of 25.06 KD. It has an overall GC content of 44.5% (A: U: C: G = 164: 200: 148: 153 = 24.66%: 30.07%: 22.25%: 23.....
Document: The ORF of the M protein, which has a defined 5′ transcription regulation sequence (TRS) (5′-CUAAAC-3′), is located between the ORFs for the E protein and PUP3 (putative uncharacterized protein 3) (6). The ORF is 666 nucleotides (nt) long, encoding a protein of 220 (+1) amino acid (a.a.) residues with a predicted molecular weight of 25.06 KD. It has an overall GC content of 44.5% (A: U: C: G = 164: 200: 148: 153 = 24.66%: 30.07%: 22.25%: 23.00%), significantly higher than that of the genome average (40.8%) (Figure 1-I). Its higher GC content is largely due to the higher fraction of hydrophobic amino acids. The amino acid composition of the M protein is summarized in Table 1.
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