Selected article for: "feedback loop and positive feedback loop"
Author: Sneha Rath; Eliza Prangley; Jesse Donovan; Kaitlin Demarest; Yigal Meir; Ned Wingreen; Alexei Korennykh
Title: Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response
  • Document date: 2018_12_4
    • ID: ng5c7xai_77
    Snippet: In order to explain the observation that the rate of increase of IFNs is only slightly reduced in the presence of RNase L, we generalize the above model by assuming that the IFN positive feedback loop is mediated by a stable activator (e.g. the IFN protein and phosphorylation of the transcription factor STAT) which do not get cleaved by RNase L. They provide a gradually accumulating activator, increasing stimulating IFN mRNA transcription with ti.....
    Document: In order to explain the observation that the rate of increase of IFNs is only slightly reduced in the presence of RNase L, we generalize the above model by assuming that the IFN positive feedback loop is mediated by a stable activator (e.g. the IFN protein and phosphorylation of the transcription factor STAT) which do not get cleaved by RNase L. They provide a gradually accumulating activator, increasing stimulating IFN mRNA transcription with time. Denoting by I(t) and A(t) the concentrations of IFN mRNAs and the IFN proteins, respectively, the rate equations that describe the system become:

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