Author: Perlman, Stanley
Title: The Middle East Respiratory Syndrome—How Worried Should We Be? Document date: 2013_8_20
ID: r52vu3p8_23
Snippet: A second major goal will be to better understand the unique features of MERS. Does the high mortality rate reflect infection primarily of patients with substantial comorbidities? Does lack of recognition by host innate immune sensors result in high levels of virus in the lung and a dysregulated immune response, as occurred in patients with SARS? Does MERS-CoV inhibit interferon induction by novel mechanisms not utilized by other coronaviruses? Do.....
Document: A second major goal will be to better understand the unique features of MERS. Does the high mortality rate reflect infection primarily of patients with substantial comorbidities? Does lack of recognition by host innate immune sensors result in high levels of virus in the lung and a dysregulated immune response, as occurred in patients with SARS? Does MERS-CoV inhibit interferon induction by novel mechanisms not utilized by other coronaviruses? Do the accessory proteins have novel mechanisms of action?
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